Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes.
Int J Parasitol
; 43(11): 869-74, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23872520
ABSTRACT
The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium berghei
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Serpinas
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Proteínas de Insectos
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Anopheles
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article