[(18)F]Fallypride: metabolism studies and quantification of the radiotracer and its radiometabolites in plasma using a simple and rapid solid-phase extraction method.

Peyronneau, Marie-Anne; Saba, Wadad; Goutal, Sébastien; Kuhnast, Bertrand; Dollé, Frédéric; Bottlaender, Michel; Valette, Héric

Peyronneau, Marie-Anne; Saba, Wadad; Goutal, Sébastien; Kuhnast, Bertrand; Dollé, Frédéric; Bottlaender, Michel; Valette, Héric.

Peyronneau MA; CEA, I2BM, Service Hospitalier Frédéric Joliot, F-91406 Orsay, France. Electronic address: marie-anne.peyronneau@cea.fr.

Nucl Med Biol ; 40(7): 887-95, 2013 Oct.

Article en En | MEDLINE | ID: mdl-23891202

Asunto(s)

Benzamidas/sangre; Benzamidas/metabolismo; Pirrolidinas/sangre; Pirrolidinas/metabolismo; Extracción en Fase Sólida/métodos; Animales; Benzamidas/química; Humanos; Cinética; Masculino; Microsomas Hepáticos/metabolismo; Papio; Pirrolidinas/química; Trazadores Radiactivos; Radioquímica; Ratas

Palabras clave

(18)F fallypride; BCA; Bicinchoninic acid; D2/D3 receptor; Fallypride; High performance liquid chromatography mass spectrometry; LCMS; MCX; Mixed mode Cation eXchange (Oasis® SPE cartridge); N-([(2S)-1-(2-propenyl)-2-pyrrolidinyl]methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; NADPH; Nicotinamide adenine dinucleotide phosphate; PET; Radiometabolites; SPE; Solid Phase Extraction; Tracer kinetics

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirrolidinas / Benzamidas / Extracción en Fase Sólida Límite: Animals / Humans / Male Idioma: En Año: 2013 Tipo del documento: Article

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