Candida albicans is not always the preferential yeast colonizing humans: a study in Wayampi Amerindians.
J Infect Dis
; 208(10): 1705-16, 2013 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-23904289
ABSTRACT
In industrialized countries Candida albicans is considered the predominant commensal yeast of the human intestine, with approximately 40% prevalence in healthy adults. We discovered a highly original colonization pattern that challenges this current perception by studying in a 4- year interval a cohort of 151 Amerindians living in a remote community (French Guiana), and animals from their environment. The prevalence of C. albicans was persistently low (3% and 7% of yeast carriers). By contrast, Candida krusei and Saccharomyces cerevisiae were detected in over 30% of carriers. We showed that C. krusei and S. cerevisiae carriage was of food or environmental origin, whereas C. albicans carriage was associated with specific risk factors (being female and living in a crowded household). We also showed using whole-genome sequence comparison that C. albicans strains can persist in the intestinal tract of a healthy individual over a 4-year period.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Candida albicans
/
Intestinos
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Animals
/
Female
/
Humans
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Male
/
Middle aged
País como asunto:
America do sul
/
Guyana francesa
Idioma:
En
Año:
2013
Tipo del documento:
Article