Kaposi's sarcoma in three HIV-1-infected cohorts.
J Acquir Immune Defic Syndr (1988)
; 3 Suppl 1: S38-43, 1990.
Article
en En
| MEDLINE
| ID: mdl-2395084
ABSTRACT
We describe the Kaposi's sarcoma (KS) experience in three cohorts of homosexual men, subjects with hemophilia, and human immunodeficiency virus type 1 (HIV-1) seroconverters. The risk of KS was higher in HIV-1-infected homosexual men from New York City as compared with Washington, D.C. and was very low in the hemophilia subjects. While KS accounted for a decreasing proportion of AIDS cases in homosexual men, the absolute risk per year did not diminish. Survival was similar after diagnosis of KS vs. opportunistic infection including Pneumocystis carinii pneumonia. Percent CD4+ and CD8+ T cells, and beta 2-microglobulin levels were less abnormal in subjects who later developed KS than in those who developed opportunistic infections; conversely, serum neopterin abnormalities were greater in those who developed KS. The additional risk of KS in homosexual men may explain their apparently higher incidence of AIDS. Further investigation of the differences in intermediate markers of KS and opportunistic infections may shed light on the pathogenesis of these particular manifestations of AIDS.
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Banco de datos:
MEDLINE
Asunto principal:
Sarcoma de Kaposi
/
Síndrome de Inmunodeficiencia Adquirida
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
País como asunto:
America do norte
Idioma:
En
Año:
1990
Tipo del documento:
Article