Identification of chiral alkenyl- and alkynylcarbinols as pharmacophores for potent cytotoxicity.
ChemMedChem
; 8(11): 1779-86, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-24014463
ABSTRACT
Illumination by acetylene Systematic structural variations in a series of archetypal acetylenic lipids derived from the naturally occurring (S,E)-icos-4-en-1-yn-3-ol allowed the discovery of a series of 3R-like 1,4-di-unsaturated carbinol units with a significant and systematic enantiomeric effect on cytotoxicity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Metanol
/
Alcanos
/
Alquenos
/
Descubrimiento de Drogas
/
Antineoplásicos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article