Design of a comprehensive Alzheimer's disease clinic and research center in Spain to meet critical patient and family needs.
Alzheimers Dement
; 10(3): 409-15, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24035148
ABSTRACT
OBJECTIVES:
Alzheimer's disease (AD) affects people worldwide, and the prevalence is increasing as the population ages. There is an international effort to understand the biology of AD to develop primary and secondary prevention strategies, and to develop effective therapeutic interventions for individuals who are already symptomatic. One of the critically important pieces of all national plans to address AD is the call for the development of service models to deliver quality, effective care based on the best evidence available.METHODS:
We describe one type of care model developed by the Fundacio ACE, Institut Catala de Neurociencies Aplicades (Fundacio ACE, Barcelona, Spain) that integrates diagnosis, therapy, follow-up care, daycare, and a day hospital, and does so in the context of an active clinical research and educational program.RESULTS:
There were 13,048 individuals newly evaluated and diagnosed in Fundacio ACE between 1996 and 2011. Of these, 6132 had AD (47.0%), 3871 had mild cognitive impairment (MCI) (29.7%), and 1958 had no cognitive impairment (15.0%). Follow-up information is available on 4735 (47.3%) AD and MCI patients, and these data indicate that MCI develops into dementia at a rate of 222.6/1000 person-years. Apolipoprotein E (APOE) genotyping was available in 22.4% of the patients. The ε4 allele occurred in 45.7% of the AD patients, in 37.8% of the MCI subjects, and in 31.6% of those without cognitive impairment.CONCLUSIONS:
Fundació ACE can serve as a model system that can be adapted to other settings within their specific cultural, governmental, and legal constraints.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Atención a la Salud
/
Enfermedad de Alzheimer
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Instituciones de Atención Ambulatoria
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
País como asunto:
Europa
Idioma:
En
Año:
2014
Tipo del documento:
Article