Lysine residues of IGF-I are substrates for transglutaminases and modulate downstream IGF-I signalling.

Sivaramakrishnan, Manaswini; Croll, Tristan I; Gupta, Rajesh; Stupar, Dario; Van Lonkhuyzen, Derek R; Upton, Zee; Shooter, Gary K

Sivaramakrishnan, Manaswini; Croll, Tristan I; Gupta, Rajesh; Stupar, Dario; Van Lonkhuyzen, Derek R; Upton, Zee; Shooter, Gary K.

Sivaramakrishnan M; Queensland University of Technology, Faculty of Health, Institute of Health and Biomedical Innovation, Kelvin Grove, Brisbane, QLD 4059, Australia. Electronic address: manaswini.sivaramakrishnan@uqconnect.edu.au.
Croll TI; Queensland University of Technology, Faculty of Health, Institute of Health and Biomedical Innovation, Kelvin Grove, Brisbane, QLD 4059, Australia.
Gupta R; Queensland University of Technology, Faculty of Health, Institute of Health and Biomedical Innovation, Kelvin Grove, Brisbane, QLD 4059, Australia.
Stupar D; Queensland University of Technology, Faculty of Health, Institute of Health and Biomedical Innovation, Kelvin Grove, Brisbane, QLD 4059, Australia.
Van Lonkhuyzen DR; Queensland University of Technology, Faculty of Health, Institute of Health and Biomedical Innovation, Kelvin Grove, Brisbane, QLD 4059, Australia.
Upton Z; Queensland University of Technology, Faculty of Health, Institute of Health and Biomedical Innovation, Kelvin Grove, Brisbane, QLD 4059, Australia.
Shooter GK; Queensland University of Technology, Faculty of Health, Institute of Health and Biomedical Innovation, Kelvin Grove, Brisbane, QLD 4059, Australia.

Biochim Biophys Acta ; 1833(12): 3176-3185, 2013 Dec.

Article en En | MEDLINE | ID: mdl-24036101

Asunto(s)

Factor I del Crecimiento Similar a la Insulina/química; Factor I del Crecimiento Similar a la Insulina/metabolismo; Lisina/metabolismo; Transglutaminasas/metabolismo; Secuencia de Aminoácidos; Movimiento Celular/efectos de los fármacos; Reactivos de Enlaces Cruzados/metabolismo; Activación Enzimática/efectos de los fármacos; Factor XIIIa/metabolismo; Humanos; Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina/metabolismo; Cinética; Células MCF-7; Espectrometría de Masas; Datos de Secuencia Molecular; Péptidos/química; Péptidos/metabolismo; Estructura Terciaria de Proteína; Proteínas Proto-Oncogénicas c-akt/metabolismo; Receptor IGF Tipo 1/metabolismo; Proteínas Recombinantes de Fusión/química; Proteínas Recombinantes de Fusión/metabolismo; Transducción de Señal/efectos de los fármacos; Relación Estructura-Actividad; Especificidad por Sustrato/efectos de los fármacos; Resonancia por Plasmón de Superficie; Vitronectina/farmacología

Palabras clave

D-domain of IGF-I; ECM; FN; FXIIIa; IGF binding proteins; IGF-I; IGFBPs; Insulin-like growth factor-1; Migration; RTK; SPR; TG2; TGases; Transglutaminase; VN; Viability; extra-cellular matrix; factor thirteen transglutaminase; fibronectin; receptor tyrosine kinases; surface plasmon resonance; tissue transglutaminase; transglutaminases; vitronectin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Transglutaminasas / Lisina Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2013 Tipo del documento: Article

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