Ventilatory response to carbon dioxide output in subjects with congestive heart failure and in patients with COPD with comparable exercise capacity.
Respir Care
; 59(7): 1034-41, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24046458
ABSTRACT
BACKGROUND:
Patients with congestive heart failure or COPD may share an increased response in minute ventilation (VÌE) to carbon dioxide output (VÌCO2 ) during exercise. The goal of this study was to ascertain whether the VÌE/VÌCO2 slope and VÌE/VÌCO2 intercept can discriminate between subjects with congestive heart failure and those with COPD at equal peak oxygen uptake (VÌO2 ).METHODS:
We studied 46 subjects with congestive heart failure (mean age 61 ± 9 y) and 46 subjects with COPD (mean age 64 ± 8 y) who performed a cardiopulmonary exercise test.RESULTS:
The VÌE/VÌCO2 slope was significantly higher in subjects with congestive heart failure compared with those with COPD (39.5 ± 9.5 vs 31.8 ± 7.4, P < .01) at peak VÌO2 < 16 mL/kg/min, but not ≥ 16 mL/kg/min (28.3 ± 5.3 vs 28.9 ± 6.6). The VÌE/VÌCO2 intercept was significantly higher in both subgroups of subjects with COPD compared with the corresponding values in the subjects with congestive heart failure (3.60 ± 1.7 vs -0.16 ± 1.7 L/min, P < .01; 3.63 ± 2.7 vs 0.87 ± 1.5 L/min, P < .01). According to receiver operating characteristic curve analysis, when all subjects with peak VÌO2 < 16 mL/kg/min were considered, subjects with COPD had a higher likelihood to have the VÌE/VÌCO2 intercept > 2.14 L/min (0.92 sensitivity, 0.96 specificity). Regardless of peak VÌO2 , the end-tidal pressure of CO2 (PETCO2 ) at peak exercise was not different in subjects with congestive heart failure (P = .42) and was significantly higher in subjects with COPD (P < .01) compared with the corresponding unloaded PETCO2 .CONCLUSIONS:
The ventilatory response to VÌCO2 during exercise was significantly different between subjects with congestive heart failure and those with COPD in terms of the VÌE/VÌCO2 slope with moderate-to-severe reduction in exercise capacity and in terms of the VÌE/VÌCO2 intercept regardless of exercise capacity.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
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Intercambio Gaseoso Pulmonar
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Enfermedad Pulmonar Obstructiva Crónica
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Insuficiencia Cardíaca
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2014
Tipo del documento:
Article