Highly efficient synthesis of (R)-3-quinuclidinol in a space-time yield of 916 g L(-1) d(-1) using a new bacterial reductase ArQR.
Org Lett
; 15(19): 4917-9, 2013 Oct 04.
Article
en En
| MEDLINE
| ID: mdl-24050153
ABSTRACT
A new keto reductase (ArQR), identified from Agrobacterium radiobacter ECU2556, can efficiently reduce 3-quinuclidinone in excellent enantioselectivity and high space-time yield for the synthesis of (R)-3-quinuclidinol, a chiral building block of many antimuscarinic agents. This is the first time that a high yield of (R)-3-quinuclidinol up to 916 g L(-1) d(-1) using a bioreduction approach is reported.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Quinuclidinas
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Escherichia coli
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3-Hidroxiacil-CoA Deshidrogenasa
Idioma:
En
Año:
2013
Tipo del documento:
Article