Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
Eur J Med Chem
; 69: 439-48, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-24090915
ABSTRACT
Andrographis paniculata, native to Taiwan, Mainland China and India, is a medicinal herb, which possesses various biological activities including anti-atherosclerosis. Andrographolide (1) has been identified as one of the active constituents against atherosclerosis. In continuation of our drug discovery program we synthesized few novel derivatives of 1 to improve their antidyslipidemic, LDL-oxidation and antioxidant activity. The tosylated derivative 7 has been turned out to be more potent than the parent compound and comparable activity with marketed antidyslipidemic drugs.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diterpenos
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Hiperlipidemias
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Lipoproteínas LDL
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Hipolipemiantes
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Antioxidantes
Límite:
Animals
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Humans
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Male
Idioma:
En
Año:
2013
Tipo del documento:
Article