Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy.
Stroke
; 44(12): 3482-9, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-24105700
ABSTRACT
BACKGROUND AND PURPOSE:
The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs).METHODS:
Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or NBO. The effects of NBO were also investigated on perfusion-weighted imaging, susceptibility-weighted imaging, and molecular imaging of vascular cell adhesion molecule-1 after ICH. Last, we performed neurological testing, including neuroscore, actimetry, and gait analysis (Catwalk), to study the influence of NBO on neurological outcome of mice presenting ICH.RESULTS:
Our results demonstrated that NBO, even during a short period of time, dramatically reduces the sensitivity of T2*-weighted imaging to detect ICH. Moreover, we provide evidence that the disappearance of ICH on T2*-weighted imaging could be used to improve accuracy of perfusion-weighted imaging and to allow molecular imaging after ICH. Importantly, a 30-minute NBO preparation 24 hours after ICH onset does not influence neurological outcome.CONCLUSIONS:
We provide an experimental demonstration that NBO significantly affects T2*-weighted imaging in ICH. Although this phenomenon could lead to inaccurate assessment of ICH volume, it could also be safely used to allow perfusion-weighted imaging and molecular imaging.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Terapia por Inhalación de Oxígeno
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Encéfalo
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Hemorragias Intracraneales
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article