Identification of 2-aminooxazole amides as acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy.

Kim, Hyunjin M; Smith, Michelle D; Kim, Jae-Hun; Caplen, Mary Ann; Chan, Tin Yau; McKittrick, Brian A; Cook, John A; van Heek, Margaret; Lachowicz, Jean

Kim, Hyunjin M; Smith, Michelle D; Kim, Jae-Hun; Caplen, Mary Ann; Chan, Tin Yau; McKittrick, Brian A; Cook, John A; van Heek, Margaret; Lachowicz, Jean.

Kim HM; Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: hyunjin.kim@merck.com.

Bioorg Med Chem Lett ; 23(23): 6410-4, 2013 Dec 01.

Article en En | MEDLINE | ID: mdl-24120540

Asunto(s)

Amidas/farmacología; Diacilglicerol O-Acetiltransferasa/antagonistas & inhibidores; Inhibidores Enzimáticos/farmacología; Oxazoles/farmacología; Triglicéridos/sangre; Animales; Humanos; Ratones; Estructura Molecular; Relación Estructura-Actividad

Palabras clave

DGAT1 inhibitors; Scaffold hopping; Treatment for dyslipidemia

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxazoles / Triglicéridos / Inhibidores Enzimáticos / Diacilglicerol O-Acetiltransferasa / Amidas Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Año: 2013 Tipo del documento: Article

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