Evolution of bacterial meningitis diagnosis in São Paulo State-Brazil and future challenges.
Arq Neuropsiquiatr
; 71(9B): 672-6, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-24141502
ABSTRACT
Bacterial meningitis (BM) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality. The most common cases of BM around the world, mainly in Brazil, have been caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b. Bacterial culture is the gold-standard technique for BM confirmation, but approximately 50% of suspected cases are not culture-confirmed, due to problems related to improper transportation and seeding or previous antibiotic treatment. Immunological methods present low sensitivity and have possibility of cross-reactions. Real time PCR (qPCR) is a molecular technique and has been successful used for BM diagnosis at Instituto Adolfo Lutz in São Paulo State, Brazil, since 2007. The incorporation of qPCR in the Public Health surveillance routine in our state resulted in diminishing 50% of undetermined BM cases. Our efforts are focused on qPCR implementation in the BM diagnostic routine throughout Brazil.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Meningitis Bacterianas
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
País como asunto:
America do sul
/
Brasil
Idioma:
En
Año:
2013
Tipo del documento:
Article