A human life-stage physiologically based pharmacokinetic and pharmacodynamic model for chlorpyrifos: development and validation.

Smith, Jordan Ned; Hinderliter, Paul M; Timchalk, Charles; Bartels, Michael J; Poet, Torka S

Smith, Jordan Ned; Hinderliter, Paul M; Timchalk, Charles; Bartels, Michael J; Poet, Torka S.

Smith JN; Battelle, Pacific Northwest Division, Richland, WA 99354, USA. Electronic address: jordan.smith@pnnl.gov.
Hinderliter PM; Battelle, Pacific Northwest Division, Richland, WA 99354, USA.
Timchalk C; Battelle, Pacific Northwest Division, Richland, WA 99354, USA.
Bartels MJ; Dow Chemical Company, Midland, MI, USA.
Poet TS; Battelle, Pacific Northwest Division, Richland, WA 99354, USA.

Regul Toxicol Pharmacol ; 69(3): 580-97, 2014 Aug.

Article en En | MEDLINE | ID: mdl-24200834

Asunto(s)

Cloropirifos/farmacocinética; Exposición a Riesgos Ambientales/efectos adversos; Exposición a Riesgos Ambientales/análisis; Adulto; Factores de Edad; Carboxilesterasa/sangre; Carboxilesterasa/metabolismo; Carboxilesterasa/farmacocinética; Carboxilesterasa/orina; Preescolar; Cloropirifos/análogos & derivados; Cloropirifos/sangre; Cloropirifos/metabolismo; Cloropirifos/orina; Inhibidores de la Colinesterasa/sangre; Inhibidores de la Colinesterasa/metabolismo; Inhibidores de la Colinesterasa/farmacocinética; Inhibidores de la Colinesterasa/orina; Femenino; Humanos; Lactante; Masculino; Modelos Biológicos; Piridonas/sangre; Piridonas/metabolismo; Piridonas/farmacocinética; Piridonas/orina

Palabras clave

Life-stage sensitivity; Pesticide; Pharmacokinetics

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cloropirifos / Exposición a Riesgos Ambientales Tipo de estudio: Prognostic_studies Límite: Adult / Child, preschool / Female / Humans / Infant / Male Idioma: En Año: 2014 Tipo del documento: Article

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