Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis.

Dowty, Martin E; Jesson, Michael I; Ghosh, Sarbani; Lee, Jamie; Meyer, Debra M; Krishnaswami, Sriram; Kishore, Nandini

Dowty, Martin E; Jesson, Michael I; Ghosh, Sarbani; Lee, Jamie; Meyer, Debra M; Krishnaswami, Sriram; Kishore, Nandini.

Dowty ME; Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Andover, Massachusetts (M.E.D.); Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, Massachusetts (M.I.J.); Pfizer Worldwide Research and Development, Chesterfield, Missouri (S.G., N.K.); Biotherapeutics, Pharmaceutical Sciences, Analytical Research and Development, Pfizer Worldwide Research and Development, Pfizer Inc, Chesterfield, Missouri (J.L., D.M.M.

J Pharmacol Exp Ther ; 348(1): 165-73, 2014 Jan.

Article en En | MEDLINE | ID: mdl-24218541

Asunto(s)

Artritis Experimental/tratamiento farmacológico; Janus Quinasa 1/antagonistas & inhibidores; Piperidinas/farmacología; Inhibidores de Proteínas Quinasas/farmacología; Pirimidinas/farmacología; Pirroles/farmacología; Animales; Artritis Experimental/enzimología; Método Doble Ciego; Evaluación Preclínica de Medicamentos/métodos; Humanos; Janus Quinasa 1/metabolismo; Janus Quinasa 3/antagonistas & inhibidores; Janus Quinasa 3/fisiología; Masculino; Ratones; Ratones Endogámicos DBA; Piperidinas/uso terapéutico; Inhibidores de Proteínas Quinasas/uso terapéutico; Pirimidinas/uso terapéutico; Pirroles/uso terapéutico

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperidinas / Artritis Experimental / Pirimidinas / Pirroles / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2014 Tipo del documento: Article

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