Brain motilin-like peptides are localized within the cell nucleus.
Peptides
; 6(6): 1119-23, 1985.
Article
en En
| MEDLINE
| ID: mdl-2422633
ABSTRACT
The subcellular localization of motilin-like immunoreactive (MLIP) peptides in comparison to vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine amide-27-like peptide (PLP) was investigated in rat brain applying different subcellular fractionation techniques. Unlike VIP or PLP, motilin-like peptides were not located in synaptosomes, but in the cell nucleus. This is the first report of a non-vesicular localization of this neuropeptide and is suggestive of a possible non-neurotransmitter role of MLIP. Previous developmental studies point to a possible role for motilin-like peptides as trophic or developmental factors. These results open the possibility that brain motilin-like peptides may operate by binding to chromatin and regulating gene expression.
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Banco de datos:
MEDLINE
Asunto principal:
Química Encefálica
/
Motilina
/
Núcleo Celular
Límite:
Animals
Idioma:
En
Año:
1985
Tipo del documento:
Article