A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease.
Cell Rep
; 5(4): 952-60, 2013 Nov 27.
Article
en En
| MEDLINE
| ID: mdl-24239353
ABSTRACT
Expression of the human Parkinson-disease-associated protein α-synuclein in all Drosophila neurons induces progressive locomotor deficits. Here, we identify a group of 15 dopaminergic neurons per hemisphere in the anterior medial region of the brain whose disruption correlates with climbing impairments in this model. These neurons selectively innervate the horizontal ß and ß' lobes of the mushroom bodies, and their connections to the Kenyon cells are markedly reduced when they express α-synuclein. Using selective mushroom body drivers, we show that blocking or overstimulating neuronal activity in the ß' lobe, but not the ß or γ lobes, significantly inhibits negative geotaxis behavior. This suggests that modulation of the mushroom body ß' lobes by this dopaminergic pathway is specifically required for an efficient control of startle-induced locomotion in flies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
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Dopamina
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Modelos Animales de Enfermedad
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Drosophila melanogaster
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Neuronas Dopaminérgicas
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Locomoción
Límite:
Animals
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Female
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Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article