LPS potentiates nucleotide-induced inflammatory gene expression in macrophages via the upregulation of P2Y2 receptor.

Eun, So Young; Seo, Jihye; Park, Sang Won; Lee, Jae Heun; Chang, Ki Churl; Kim, Hye Jung

Eun, So Young; Seo, Jihye; Park, Sang Won; Lee, Jae Heun; Chang, Ki Churl; Kim, Hye Jung.

Eun SY; Department of Pharmacology, School Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Seo J; Department of Pharmacology, School Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Park SW; Department of Pharmacology, School Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Lee JH; Department of Pharmacology, School Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Chang KC; Department of Pharmacology, School Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Kim HJ; Department of Pharmacology, School Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea. Electronic address: hyejungkim@gnu.ac.kr.

Int Immunopharmacol ; 18(2): 270-6, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24316256

Asunto(s)

Adenosina Trifosfato/metabolismo; Lipopolisacáridos/farmacología; Macrófagos/efectos de los fármacos; Receptores Purinérgicos P2Y2/genética; Proteínas Quinasas Dependientes de 3-Fosfoinosítido/metabolismo; Adenosina Trifosfato/farmacología; Animales; Línea Celular; Ciclooxigenasa 2/metabolismo; Dinoprostona/metabolismo; Expresión Génica; Proteína HMGB1/genética; Inflamación/genética; Inflamación/metabolismo; MAP Quinasa Quinasa 4/metabolismo; Macrófagos/metabolismo; Ratones; Óxido Nítrico/metabolismo; Óxido Nítrico Sintasa de Tipo II/metabolismo; Proteína Quinasa C/metabolismo; ARN Mensajero/biosíntesis; ARN Interferente Pequeño/genética; Regulación hacia Arriba; Uridina Trifosfato/farmacología

Palabras clave

ANOVA; COX-1/PGE(2); COX-2; HEPES; HMGB1; LPS; N-(2-hydroxyethyl)piperazine-N-2-ethanesulfonic acid; NO; Nucleotides; P2Y(2) receptor; P2Y(2)R; PDK; PGE2; PI3K; PKC; RT-PCR; SDS-PAGE; TBS-T; Tris-buffered saline-Tween-20; analysis of variance; cyclooxygenase-2; iNOS; iNOS/NO; inducible nitric oxide synthase; lipopolysaccharide; nitric oxide; phosphatidylinositol 3-kinase; phosphoinositide-dependent kinase; prostaglandin E2; protein kinase C; reverse transcription-polymerase chain reaction; sodium dodecyl sulfate-polyacrylamide gel electrophoresis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Lipopolisacáridos / Receptores Purinérgicos P2Y2 / Macrófagos Límite: Animals Idioma: En Año: 2014 Tipo del documento: Article

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