Probing DNA by 2-OG-dependent dioxygenase.

Tsai, Chi-Lin; Tainer, John A

Tsai, Chi-Lin; Tainer, John A.

Tsai CL; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Tainer JA; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Molecular Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: jat@scripps.edu.

Cell ; 155(7): 1448-50, 2013 Dec 19.

Article en En | MEDLINE | ID: mdl-24360270

ABSTRACT

ABSTRACT

TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.

Asunto(s)

5-Metilcitosina/metabolismo; Proteínas de Unión al ADN/química; Proteínas de Unión al ADN/metabolismo; ADN/química; ADN/metabolismo; Proteínas Proto-Oncogénicas/química; Proteínas Proto-Oncogénicas/metabolismo; Dioxigenasas; Humanos

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN / Proteínas Proto-Oncogénicas / 5-Metilcitosina / Proteínas de Unión al ADN Límite: Humans Idioma: En Año: 2013 Tipo del documento: Article

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