The association of host and genetic melanoma risk factors with Breslow thickness in the Western Australian Melanoma Health Study.
Br J Dermatol
; 170(4): 851-7, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24405011
ABSTRACT
BACKGROUND:
Breslow thickness is the most important predictor of survival in localized malignant melanoma. A number of melanoma risk factors have been shown to be associated with Breslow thickness; however, the role of genetic loci has been little investigated to date.OBJECTIVES:
To investigate the association of known melanoma susceptibility genetic loci with Breslow thickness.METHODS:
Participants were 800 individuals from the Western Australian Melanoma Health Study who completed a questionnaire and provided a DNA sample. Genetic association analyses between single-nucleotide polymorphisms (SNPs) from 15 candidate melanoma susceptibility genes and Breslow thickness were performed, controlling for relevant covariates.RESULTS:
Older age at diagnosis and absence of naevi were associated with increased Breslow thickness. Following adjustment for multiple testing, no SNPs were significantly associated with Breslow thickness.CONCLUSIONS:
Associations observed between Breslow thickness and age and naevi reinforce current knowledge. Some evidence of shared genetic determinants between melanoma risk and Breslow thickness was found. Further studies are required to confirm this finding.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Polimorfismo de Nucleótido Simple
/
Melanoma
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
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Male
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Middle aged
País como asunto:
Oceania
Idioma:
En
Año:
2014
Tipo del documento:
Article