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Chemoenzymatic synthesis of ADP-d-glycero-ß-d-manno-heptose and study of the substrate specificity of HldE.
Li, Tiehai; Wen, Liuqing; Williams, Adriel; Wu, Baolin; Li, Lei; Qu, Jingyao; Meisner, Jeffrey; Xiao, Zhongying; Fang, Junqiang; Wang, Peng George.
  • Li T; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
  • Wen L; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
  • Williams A; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
  • Wu B; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
  • Li L; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
  • Qu J; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
  • Meisner J; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
  • Xiao Z; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA.
  • Fang J; National Glycoengineering Research Center, Shandong University, Jinan, Shandong 250100, People's Republic of China.
  • Wang PG; Department of Chemistry, Center for Therapeutics and Diagnostics, Georgia State University, Atlanta, GA 30303, USA; National Glycoengineering Research Center, Shandong University, Jinan, Shandong 250100, People's Republic of China. Electronic address: pwang11@gsu.edu.
Bioorg Med Chem ; 22(3): 1139-47, 2014 Feb 01.
Article en En | MEDLINE | ID: mdl-24412338
An efficient one-pot three enzymes strategy for chemoenzymatic synthesis of ADP-d-glycero-ß-d-manno-heptose (ADP-d, d-heptose) was reported using chemically synthesized d, d-heptose-7-phosphate and the ADP-d, d-heptose biosynthetic enzymes HldE and GmhB. Moreover, the result of investigating substrate specificity of the kinase action of HldE revealed that HldE had highly restricted substrate specificity towards structurally modified heptose-7-phosphate analogs.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azúcares de Adenosina Difosfato / Fosfotransferasas (Aceptor de Grupo Alcohol) / Complejos Multienzimáticos / Nucleotidiltransferasas Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azúcares de Adenosina Difosfato / Fosfotransferasas (Aceptor de Grupo Alcohol) / Complejos Multienzimáticos / Nucleotidiltransferasas Idioma: En Año: 2014 Tipo del documento: Article