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The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-ß signaling.
Borkham-Kamphorst, Erawan; Schaffrath, Christian; Van de Leur, Eddy; Haas, Ute; Tihaa, Lidia; Meurer, Steffen K; Nevzorova, Yulia A; Liedtke, Christian; Weiskirchen, Ralf.
  • Borkham-Kamphorst E; Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany. Electronic address: ekamphorst@ukaachen.de.
  • Schaffrath C; Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany.
  • Van de Leur E; Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany.
  • Haas U; Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany.
  • Tihaa L; Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany.
  • Meurer SK; Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany.
  • Nevzorova YA; Department of Internal Medicine III, RWTH Aachen University Hospital, Germany.
  • Liedtke C; Department of Internal Medicine III, RWTH Aachen University Hospital, Germany.
  • Weiskirchen R; Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany. Electronic address: rweiskirchen@ukaachen.de.
Biochim Biophys Acta ; 1843(5): 902-14, 2014 May.
Article en En | MEDLINE | ID: mdl-24487063
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Factor de Crecimiento Transformador beta / Senescencia Celular / Especies Reactivas de Oxígeno / Apoptosis / Proteína 61 Rica en Cisteína / Miofibroblastos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2014 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Factor de Crecimiento Transformador beta / Senescencia Celular / Especies Reactivas de Oxígeno / Apoptosis / Proteína 61 Rica en Cisteína / Miofibroblastos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2014 Tipo del documento: Article