Enantioselective desymmetrization of diesters.
J Org Chem
; 79(5): 2303-7, 2014 Mar 07.
Article
en En
| MEDLINE
| ID: mdl-24506346
ABSTRACT
The desymmetrization of prochiral diesters with a chiral phosphoric acid catalyst to produce highly enantioenriched lactones in excellent yield is reported. The process is easily scaled and accommodates a variety of substitution patterns, many of which result in the generation of an enantioenriched all-carbon quaternary center. Manipulation of lactone product to useful small building blocks is also described.
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MEDLINE
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2014
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Article