Anti-allergic effect of a Korean traditional medicine, Biyeom-Tang on mast cells and allergic rhinitis.
BMC Complement Altern Med
; 14: 54, 2014 Feb 12.
Article
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| MEDLINE
| ID: mdl-24521096
ABSTRACT
BACKGROUND:
Biyeom-Tang, a medicine prescribed by oriental clinics, has been used for the treatment of the allergic rhinitis (AR). In the present study, an ethanol extract of Biyeom-Tang (EBT) was investigated for anti-allergic properties on bone-marrow derived mast cells (BMMC) and in vivo models.METHODS:
The anti-allergic properties of EBT were evaluated by measuring ß-Hex release and the production of prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) on BMMC in vitro and PCA and OVA-induced AR models in vivo.RESULTS:
EBT strongly inhibited a degranulation reaction in a dose dependent manner with an IC50 value of 35.6 µg/ml. In addition, the generation of PGD2 and LTC4 was inhibited in BMMC in a concentration-dependent manner with IC50 values of 7.0 µg/ml and 10.9 µg/ml, respectively. When administrated orally, EBT ameliorated the mast cell-mediated PCA reaction. In the OVA-induced AR model, the increased levels of IgE were reduced by EBT. The levels of cytokines, such as IL-4, IL-5, IL-10, and IL-13 decreased in the splenocytes of EBT-treated mice. The histological analysis shows that the infiltration of inflammatory cells increased by OVA-sensitization was also reduced.CONCLUSIONS:
Taken together, these results suggested that EBT has anti-allergic and anti-inflammatory effects in vitro and in vivo models.
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Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
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Prostaglandina D2
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Interleucinas
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Antialérgicos
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Rinitis Alérgica
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Mastocitos
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Fitoterapia
Límite:
Animals
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En
Año:
2014
Tipo del documento:
Article