Nickel-catalyzed Csp2-Csp3 bond formation by carbon-fluorine activation.
Chemistry
; 20(11): 3162-8, 2014 Mar 10.
Article
en En
| MEDLINE
| ID: mdl-24522982
ABSTRACT
We report herein a general catalytic method for Csp(2)-Csp(3) bond formation through C-F activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with ß-hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complejos de Coordinación
/
Flúor
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Halógenos
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Níquel
Idioma:
En
Año:
2014
Tipo del documento:
Article