Early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of Enterobacter.
J Pediatr
; 165(1): 23-9, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24529620
ABSTRACT
OBJECTIVES:
To determine the impact of empiric ampicillin and gentamicin use in the first week of life on microbial colonization and diversity in preterm infants. STUDYDESIGN:
The 16s ribosomal DNA community profiling was used to compare the microbiota of 74 infants born ≤32 weeks gestational age by degree of antibiotic use in the first week of life. The degree of antibiotic use was classified as 0 days, 1-4 days, and 5-7 days of antibiotic administration. All of the antibiotic use was empiric, defined as treatment based solely on clinical suspicion of infection without a positive culture result.RESULTS:
Infants who received 5-7 days of empiric antimicrobial agents in the first week had increased relative abundance of Enterobacter (P = .016) and lower bacterial diversity in the second and third weeks of life. Infants receiving early antibiotics also experienced more cases of necrotizing enterocolitis, sepsis, or death than those not exposed to antibiotics.CONCLUSIONS:
Early empiric antibiotics have sustained effects on the intestinal microbiota of preterm infants. Intestinal dysbiosis in this population has been found to be associated with elevated risk of necrotizing enterocolitis, sepsis, or death.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Recien Nacido Prematuro
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Enterobacter
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Microbiota
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Intestinos
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Antibacterianos
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Newborn
País como asunto:
America do norte
Idioma:
En
Año:
2014
Tipo del documento:
Article