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A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.
Ferreira, Ricardo C; Guo, Hui; Coulson, Richard M R; Smyth, Deborah J; Pekalski, Marcin L; Burren, Oliver S; Cutler, Antony J; Doecke, James D; Flint, Shaun; McKinney, Eoin F; Lyons, Paul A; Smith, Kenneth G C; Achenbach, Peter; Beyerlein, Andreas; Dunger, David B; Clayton, David G; Wicker, Linda S; Todd, John A; Bonifacio, Ezio; Wallace, Chris; Ziegler, Anette-G.
  • Ferreira RC; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
  • Guo H; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
  • Coulson RM; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.Cambridge Institute for Medical Research and Department of Medicine, University of Ca
  • Smyth DJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
  • Pekalski ML; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
  • Burren OS; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
  • Cutler AJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
  • Doecke JD; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.The Australian E-Health Research Centre, Royal Brisbane and Women's Hospital, Queensl
  • Flint S; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, U.K.
  • McKinney EF; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, U.K.
  • Lyons PA; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, U.K.
  • Smith KG; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, U.K.
  • Achenbach P; Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, München, Germany.
  • Beyerlein A; Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, München, Germany.
  • Dunger DB; Department of Paediatrics, School of Clinical Medicine, University of Cambridge, Cambridge, U.K.
  • Clayton DG; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
  • Wicker LS; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
  • Todd JA; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K. john.todd@cimr.cam.ac.uk chris.wallace@cimr.cam.ac.uk anette-g.ziegler@helmholtz-mue
  • Bonifacio E; CRTD-DFG Research Center for Regenerative Therapies Dresden and Paul Langerhans Institute Dresden, Technische Universität Dresden, Dresden, Germany.
  • Wallace C; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K. john.todd@cimr.cam.ac.uk chris.wallace@cimr.cam.ac.uk anette-g.ziegler@helmholtz-mue
  • Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, München, Germany john.todd@cimr.cam.ac.uk chris.wallace@cimr.cam.ac.uk anette-g.ziegler@helmholtz-muenchen.de.
Diabetes ; 63(7): 2538-50, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24561305
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Interferón Tipo I / Autoinmunidad / Diabetes Mellitus Tipo 1 / Transcriptoma Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Interferón Tipo I / Autoinmunidad / Diabetes Mellitus Tipo 1 / Transcriptoma Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Año: 2014 Tipo del documento: Article