Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin.
Nano Lett
; 14(4): 2130-4, 2014.
Article
en En
| MEDLINE
| ID: mdl-24564342
ABSTRACT
Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Glicoconjugados
/
Dióxido de Silicio
/
Selectina-P
/
Selectina E
/
Accidente Cerebrovascular
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Nanopartículas de Magnetita
/
Inflamación
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2014
Tipo del documento:
Article