Netamines H-N, tricyclic alkaloids from the marine sponge Biemna laboutei and their antimalarial activity.
J Nat Prod
; 77(4): 818-23, 2014 Apr 25.
Article
en En
| MEDLINE
| ID: mdl-24601655
ABSTRACT
Chemical examination of the CH2Cl2-MeOH (11) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 µM.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
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Poríferos
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Quinazolinas
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Alcaloides
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Antimaláricos
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Antineoplásicos Fitogénicos
Límite:
Animals
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Humans
País como asunto:
Africa
Idioma:
En
Año:
2014
Tipo del documento:
Article