Pseudobulbar paralysis in the Renaissance: Cosimo I de' Medici case.
Neurol Sci
; 35(7): 1133-7, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24604411
ABSTRACT
Cosimo I de' Medici (1519-1574) was the first Grand Duke of Tuscany. He was one of the most important members of the Medici family. He was an excellent conqueror and a good politician. Moreover, he was able to attract and encourage artists, scientists and architects to promote Florence as the cultural capital of the Italian Renaissance. Historical chronicles report that he suffered from a stroke when he was 49 years old. Together with the acute manifestation of stroke, he displayed peculiar symptoms. He had gait disturbances and sphincter dysfunctions. His language became poor and hard to understand. His mood was very fluctuating and in the last years of his life he was a short-tempered man. In addition, he had a characteristic symptom, so-called pathological laughing and crying. The course of his disease was slow and stuttering. Taken together, these data seem to be one of the first reports of pseudobulbar paralysis. The disease of Cosimo I was probably due to a chronic cerebral vasculopathy, known as small vessels disease. We discuss this hypothesis regarding an ancient clinical case, with the support of current studies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Parálisis Seudobulbar
/
Historia Medieval
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
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Male
/
Middle aged
País como asunto:
Europa
Idioma:
En
Año:
2014
Tipo del documento:
Article