Tubular urinary biomarkers do not identify aetiology of acute kidney injury in kidney transplant recipients.
Nephrology (Carlton)
; 19(6): 352-8, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24666430
ABSTRACT
AIM:
To evaluate the performance of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule, interleukin-18 and heat shock protein 72 for differential diagnosis between causes of acute kidney injury in kidney transplant recipients, especially immunological rejection. PATIENTS ANDMETHODS:
We measured these biomarkers in 67 kidney transplant recipients with acute kidney injury according to the RIFLE criteria.RESULTS:
There were no statistical differences in biomarkers between kidney transplant recipients with immunological rejection (n = 20), pre-renal causes (n = 20) and other AKI causes (n = 27). Only the uNGAL level relative to urinary creatinine (uNGAL/uCr) for immunological rejection was different in comparison with others (P < 0.001); a cut-off of 59 µg/g of uNGAL/uCr had a sensitivity and specificity of 60% and 58% respectively (area under the curve in receiver-operating characteristic curve, 0.65). The other biomarkers were not useful in differentiating the causes of acute kidney injury.CONCLUSION:
The biomarkers tested are not useful in identifying immunological rejection as cause of acute kidney injury in kidney transplant recipients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
/
Lesión Renal Aguda
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Rechazo de Injerto
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Túbulos Renales
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
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Prognostic_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Año:
2014
Tipo del documento:
Article