[Comparison of ¹8F-FDG PET/CT and large-scale DWI for evaluation of non-Hodgkin lymphoma bone marrow infiltration].
Zhonghua Xue Ye Xue Za Zhi
; 35(3): 231-5, 2014 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-24666490
ABSTRACT
OBJECTIVE:
To compare the diagnostic value of ¹8F-fluorodeoxyglucose-positron emission tomography/computed tomography (¹8F-FDG PET/CT) and large-scale diffusion weighted imaging (DWI) for evaluation of non-Hodgkin lymphoma (NHL) bone marrow (BM) infiltration.METHODS:
A total of 79 patients with pathologically diagnosed NHL underwent ¹8F-FDG PET/CT, large scale DWI and BM pathological examination. BM examination as the "gold standard", the performance (the sensitivity, specificity, accuracy, positive and negative predictive value) of ¹8F-FDG PET/CT and large scale DWI for evaluation of BM infiltration was compared and the risk of BM infiltration of different subtypes and sources of NHL was analyzed.RESULTS:
25 of 79 cases were diagnosed as BM infiltration by pathological examination with 57 BM sites. Abnormal high BM metabolisms were identified in 22 cases with 56 BM sites by ¹8F-FDG PET/CT and 25 cases with 58 BM sites by large-scale DWI. The sensitivity, specificity, accuracy, positive and negative predictive value of ¹8F-FDG PET/CT were 80.0%, 96.3%, 91.1%, 90.9%, 91.2%, respectively. And they were 84.0%, 92.6%, 89.9%, 84.0%, and 92.6% by large-scale DWI, respectively. A receiver operating characteristic (ROC) analysis demonstrated that there was no statistical difference in ¹8F-FDG PET/CT and large-scale DWI (P>0.05). The area under ROC curve for ¹8F-FDG PET/CT and large-scale DWI were 0.911 and 0.883 respectively. The incidences of BM infiltration in aggressive NHL patients by ¹8F-FDG PET/CT (21/69, 30.4%) and large-scale DWI (23/69, 33.3%) were higher than those (PET/CT 10.0%; large-scale DWI 20.0%; P>0.05) in indolent NHL patients.CONCLUSION:
¹8F-FDG PET/CT and large-scale DWI had important clinical value in diagnosing BM infiltration of NHL. A combination of ¹8F-FDG PET/CT, large-scale DWI and pathological examination could improve the positive rate of BM infiltration in NHL.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Médula Ósea
/
Linfoma no Hodgkin
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
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Aged
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Aged80
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Female
/
Humans
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Male
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Middle aged
Idioma:
Zh
Año:
2014
Tipo del documento:
Article