Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.

Mujumdar, Nameeta; Banerjee, Sulagna; Chen, Zhiyu; Sangwan, Veena; Chugh, Rohit; Dudeja, Vikas; Yamamoto, Masato; Vickers, Selwyn M; Saluja, Ashok K

Mujumdar, Nameeta; Banerjee, Sulagna; Chen, Zhiyu; Sangwan, Veena; Chugh, Rohit; Dudeja, Vikas; Yamamoto, Masato; Vickers, Selwyn M; Saluja, Ashok K.

Mujumdar N; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and.
Banerjee S; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and.
Chen Z; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and.
Sangwan V; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and.
Chugh R; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and.
Dudeja V; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and.
Yamamoto M; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Vickers SM; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Saluja AK; Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota; and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota asaluja@umn.edu.

Am J Physiol Gastrointest Liver Physiol ; 306(11): G1011-20, 2014 Jun 01.

Article en En | MEDLINE | ID: mdl-24699326

Asunto(s)

Diterpenos/farmacología; Retículo Endoplásmico/efectos de los fármacos; Neoplasias Pancreáticas/metabolismo; Fenantrenos/farmacología; Estrés Fisiológico/efectos de los fármacos; Respuesta de Proteína Desplegada/efectos de los fármacos; Animales; Antiinflamatorios no Esteroideos/farmacología; Proteínas Reguladoras de la Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/metabolismo; Beclina-1; Línea Celular Tumoral; Enfermedad Crónica; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Regulación hacia Abajo; Retículo Endoplásmico/fisiología; Chaperón BiP del Retículo Endoplásmico; Compuestos Epoxi/farmacología; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Técnicas de Silenciamiento del Gen; Silenciador del Gen; Proteínas de Choque Térmico/genética; Proteínas de Choque Térmico/metabolismo; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Factores de Transcripción del Factor Regulador X; Factores de Transcripción/genética; Factores de Transcripción/metabolismo

Palabras clave

apoptosis; autophagy; endoplasmic reticulum stress; glucose-regulated protein 78; pancreatic cancer; triptolide

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Fenantrenos / Estrés Fisiológico / Diterpenos / Retículo Endoplásmico / Respuesta de Proteína Desplegada Límite: Animals Idioma: En Año: 2014 Tipo del documento: Article

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