High-dose porcine galanin infusion and effect on intravenous glucose tolerance in humans.
Diabetes
; 38(9): 1114-6, 1989 Sep.
Article
en En
| MEDLINE
| ID: mdl-2475378
ABSTRACT
The neuropeptide galanin inhibits glucose-stimulated insulin release in dogs and rodents and has been proposed as having a role in the control of insulin release in humans. The effect of infused galanin on intravenous glucose tolerance in humans was investigated by giving an intravenous glucose tolerance test (0.5 g glucose/kg body wt) alone and with infusions of synthetic porcine galanin at high-dose levels (80 and 160 pmol.kg-1.min-1) to seven healthy male volunteers. The results showed no effect of galanin infusion on plasma glucose or serum insulin, although a rise in serum growth hormone even in the face of the intravenous glucose load confirmed the potent growth hormone-stimulating effect of galanin. These results suggest that caution should be exercised in extrapolating a physiological role for galanin in humans from the results of animal studies.
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Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Neuropéptidos
/
Glucosa
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Año:
1989
Tipo del documento:
Article