Early hyperglycemia detected by continuous glucose monitoring in children at risk for type 1 diabetes.
Diabetes Care
; 37(7): 2031-3, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24784826
ABSTRACT
OBJECTIVE:
We explore continuous glucose monitoring (CGM) as a new approach to defining early hyperglycemia and diagnosing type 1 diabetes in children with positive islet autoantibodies (Ab+). RESEARCH DESIGN ANDMETHODS:
Fourteen Ab+ children, free of signs or symptoms of diabetes, and nine antibody-negative (Ab-) subjects, followed by the Diabetes Autoimmunity Study in the Young, were asked to wear a Dexcom SEVEN CGM.RESULTS:
The Ab+ subjects showed more hyperglycemia, with 18% time spent above 140 mg/dL, compared with 9% in Ab- subjects (P = 0.04). Their average maximum daytime glucose value was higher, and they had increased glycemic variability. The mean HbA1c in the Ab+ subjects was 5.5% (37 mmol/mol). Among Ab+ subjects, ≥18-20% CGM time spent above 140 mg/dL seems to predict progression to diabetes.CONCLUSIONS:
CGM can detect early hyperglycemia in Ab+ children who are at high risk for progression to diabetes. Proposed CGM predictors of progression to diabetes require further validation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Glucemia
/
Diabetes Mellitus Tipo 1
/
Hiperglucemia
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
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Female
/
Humans
/
Male
Idioma:
En
Año:
2014
Tipo del documento:
Article