The influence of the trichorzianin C-terminal residues on the ion channel conductance in lipid bilayers.
Biochim Biophys Acta
; 987(1): 133-6, 1989 Dec 11.
Article
en En
| MEDLINE
| ID: mdl-2480816
ABSTRACT
Four natural trichorzianin analogues, channel-forming peptaibols, differing in their C-terminal residues (Gln or Glu, Trpol or Pheol) were tested for their macroscopic and single-channel conductances in planar lipid bilayers. The results indicate that, as regards to the voltage threshold, the most efficient analogue is the charged Trpol-bearing one. In addition, Trpol brings about a drastic lengthening of the open channel life-times. This behaviour is attributed to the dipole moment of the end residues and to the bulkiness and hydrogen bonding ability of Trpol.
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Banco de datos:
MEDLINE
Asunto principal:
Canales Iónicos
/
Membrana Dobles de Lípidos
/
Antibacterianos
Idioma:
En
Año:
1989
Tipo del documento:
Article