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The histamine H4 receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects.
Kollmeier, Alexa; Francke, Klaus; Chen, Bin; Dunford, Paul J; Greenspan, Andrew J; Xia, Yichuan; Xu, Xie L; Zhou, Bei; Thurmond, Robin L.
  • Kollmeier A; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.).
  • Francke K; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.).
  • Chen B; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.).
  • Dunford PJ; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.).
  • Greenspan AJ; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.).
  • Xia Y; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.).
  • Xu XL; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.).
  • Zhou B; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.).
  • Thurmond RL; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.) rthurmon@its.jnj.com.
J Pharmacol Exp Ther ; 350(1): 181-7, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24817035
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Prurito / Pirimidinas / Pirrolidinas / Histamina / Receptores Acoplados a Proteínas G / Antagonistas de los Receptores Histamínicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Humans / Male / Middle aged Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Prurito / Pirimidinas / Pirrolidinas / Histamina / Receptores Acoplados a Proteínas G / Antagonistas de los Receptores Histamínicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Humans / Male / Middle aged Idioma: En Año: 2014 Tipo del documento: Article