Daphnane-type diterpenoid glucosides and further constituents of Euphorbia pilosa.
Chem Biodivers
; 11(5): 760-6, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24827685
ABSTRACT
Phytochemical investigation of whole plants of Euphorbia pilosa led to the isolation and identification of two new daphnane-diterpenoid glucosides, euphopilosides A and B (1 and 2, resp.), and a new ent-abietane, euphopilolide (3), together with eight known compounds. Compounds 1 and 2 are the first daphnane-type diterpenoid glycosides. Their structures were elucidated by a combination of 1D- and 2D-NMR, and MS analyses, and acid hydrolysis. Compounds 1-9 were evaluated for their in vitro cytotoxicities against five human tumor cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480. Compound 7 showed moderate inhibitory activity against all five cell lines.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Euphorbia
/
Diterpenos
/
Glucósidos
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Año:
2014
Tipo del documento:
Article