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A draft map of the human proteome.
Kim, Min-Sik; Pinto, Sneha M; Getnet, Derese; Nirujogi, Raja Sekhar; Manda, Srikanth S; Chaerkady, Raghothama; Madugundu, Anil K; Kelkar, Dhanashree S; Isserlin, Ruth; Jain, Shobhit; Thomas, Joji K; Muthusamy, Babylakshmi; Leal-Rojas, Pamela; Kumar, Praveen; Sahasrabuddhe, Nandini A; Balakrishnan, Lavanya; Advani, Jayshree; George, Bijesh; Renuse, Santosh; Selvan, Lakshmi Dhevi N; Patil, Arun H; Nanjappa, Vishalakshi; Radhakrishnan, Aneesha; Prasad, Samarjeet; Subbannayya, Tejaswini; Raju, Rajesh; Kumar, Manish; Sreenivasamurthy, Sreelakshmi K; Marimuthu, Arivusudar; Sathe, Gajanan J; Chavan, Sandip; Datta, Keshava K; Subbannayya, Yashwanth; Sahu, Apeksha; Yelamanchi, Soujanya D; Jayaram, Savita; Rajagopalan, Pavithra; Sharma, Jyoti; Murthy, Krishna R; Syed, Nazia; Goel, Renu; Khan, Aafaque A; Ahmad, Sartaj; Dey, Gourav; Mudgal, Keshav; Chatterjee, Aditi; Huang, Tai-Chung; Zhong, Jun; Wu, Xinyan; Shaw, Patrick G.
  • Kim MS; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Pinto SM; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Getnet D; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130, USA.
  • Nirujogi RS; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Manda SS; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Chaerkady R; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Madugundu AK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Kelkar DS; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Isserlin R; The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  • Jain S; The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  • Thomas JK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Muthusamy B; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Leal-Rojas P; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Pathology, Universidad de La Frontera, Center of Genetic and Immunological Studies-Scientific and Technological Bioresource Nucleus, Temuco 4811230, Chile.
  • Kumar P; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Sahasrabuddhe NA; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Balakrishnan L; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Advani J; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • George B; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Renuse S; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Selvan LD; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Patil AH; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Nanjappa V; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Radhakrishnan A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Prasad S; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Subbannayya T; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Raju R; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Kumar M; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Sreenivasamurthy SK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Marimuthu A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Sathe GJ; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Chavan S; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Datta KK; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Subbannayya Y; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Sahu A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Yelamanchi SD; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Jayaram S; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Rajagopalan P; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Sharma J; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Murthy KR; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Syed N; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Goel R; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Khan AA; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Ahmad S; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Dey G; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Mudgal K; School of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  • Chatterjee A; Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
  • Huang TC; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Zhong J; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Wu X; 1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Shaw PG; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Nature ; 509(7502): 575-81, 2014 May 29.
Article en En | MEDLINE | ID: mdl-24870542
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteoma / Proteómica Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteoma / Proteómica Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Año: 2014 Tipo del documento: Article