Toward male individualization with rapidly mutating y-chromosomal short tandem repeats.
Hum Mutat
; 35(8): 1021-32, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-24917567
ABSTRACT
Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global 0.9999985, regional 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.
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Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Haplotipos
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Dermatoglifia del ADN
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Repeticiones de Microsatélite
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Cromosomas Humanos Y
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Genética de Población
Límite:
Humans
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Male
País como asunto:
Africa
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Asia
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Europa
Idioma:
En
Año:
2014
Tipo del documento:
Article