BDNF Val66Met polymorphism in primary adult-onset dystonia: a case-control study and meta-analysis.
Mov Disord
; 29(8): 1083-6, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24925604
ABSTRACT
BACKGROUND:
A polymorphism in brain-derived neurotrophic factor (BDNF) (Val66Met) has been reported as a risk factor in primary dystonia. However, overall the results have been inconclusive. Our aim was to clarify the association of Val66Met with primary dystonia, and with the most prevalent clinical subtypes, cervical dystonia and blepharospasm.METHODS:
We conducted a Spanish multicenter case-control study (including 680 primary dystonia patients and 788 healthy controls) and performed a meta-analysis integrating our study and six previously published studies (including a total of 1,936 primary dystonia patients and 2,519 healthy controls).RESULTS:
We found no allelic or genotypic association with primary dystonia, cervical dystonia, or blepharospasm risks, for the allele A (Met) from a BDNF Val66Met polymorphism in our case-control study. This was confirmed by results from our meta-analysis in white and mixed ethnic populations in any genetic model.CONCLUSION:
We did not find any evidence supporting the association of the BDNF Val66Met polymorphism with primary dystonia.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factor Neurotrófico Derivado del Encéfalo
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Predisposición Genética a la Enfermedad
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Trastornos Distónicos
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Polimorfismo de Nucleótido Simple
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2014
Tipo del documento:
Article