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Chemogenesis of an antiangiogenic glycosaminoglycan.
Raman, Karthik; Arungundram, Sailaja; Kuberan, Balagurunathan.
  • Raman K; Department of Bioengineering, University of Utah , Salt Lake City, Utah 84112, United States.
  • Arungundram S; Department of Medicinal Chemistry, University of Utah , Salt Lake City, Utah 84112, United States.
  • Kuberan B; Department of Bioengineering, University of Utah , Salt Lake City, Utah 84112, United States ; Department of Medicinal Chemistry, University of Utah , Salt Lake City, Utah 84112, United States ; Interdepartmental Program in Neuroscience, University of Utah , Salt Lake City, Utah 84112, United States.
ACS Med Chem Lett ; 5(6): 644-6, 2014 Jun 12.
Article en En | MEDLINE | ID: mdl-24944736
ABSTRACT
In this letter we report a facile chemical conversion of heparin, a potent anticoagulant with minimal antiangiogenic activity, into an effective antiangiogenic glycosaminoglycan through optimized chemical approaches. This work highlights the potential for industrial scale production of a therapeutic anticancer glycosaminoglycan.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2014 Tipo del documento: Article