Macrophages in renal transplantation: Roles and therapeutic implications.
Cell Immunol
; 291(1-2): 58-64, 2014.
Article
en En
| MEDLINE
| ID: mdl-24973994
ABSTRACT
The presence of macrophages within transplanted renal allografts has been appreciated for some time, whereby macrophages were viewed primarily as participants in the process of cell-mediated allograft rejection. Recent insights into macrophage biology have greatly expanded our conceptual understanding of the multiple roles of macrophages within the allograft. Distinct macrophage subsets are present within the kidney and these sub-serve discrete functions in promoting and attenuating inflammation, immune modulation and tissue repair. Unraveling the complex roles macrophages play in transplantation will allow identification of potential therapeutic targets to prevent and treat allograft rejection and maximize graft longevity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Monocitos
/
Daño por Reperfusión
/
Trasplante de Riñón
/
Rechazo de Injerto
/
Inflamación
/
Riñón
Límite:
Animals
/
Humans
Idioma:
En
Año:
2014
Tipo del documento:
Article