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Indole alkaloids from marine sources as potential leads against infectious diseases.
França, Paulo H B; Barbosa, Daniel P; da Silva, Daniel L; Ribeiro, Êurica A N; Santana, Antônio E G; Santos, Bárbara V O; Barbosa-Filho, José M; Quintans, Jullyana S S; Barreto, Rosana S S; Quintans-Júnior, Lucindo J; de Araújo-Júnior, João X.
  • França PH; Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.
  • Barbosa DP; School of Nursing and Pharmacy, Federal University of Alagoas, Av. Lourival de Mello Motta, S/N, Tabuleiro dos Martins, 57072-970 Maceió, AL, Brazil.
  • da Silva DL; Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.
  • Ribeiro ÊA; School of Nursing and Pharmacy, Federal University of Alagoas, Av. Lourival de Mello Motta, S/N, Tabuleiro dos Martins, 57072-970 Maceió, AL, Brazil.
  • Santana AE; Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil.
  • Santos BV; Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900 João Pessoa, PB, Brazil.
  • Barbosa-Filho JM; Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900 João Pessoa, PB, Brazil.
  • Quintans JS; Department of Physiology, Federal University of Sergipe, 49000-100 São Cristóvão, SE, Brazil.
  • Barreto RS; Department of Physiology, Federal University of Sergipe, 49000-100 São Cristóvão, SE, Brazil.
  • Quintans-Júnior LJ; Department of Physiology, Federal University of Sergipe, 49000-100 São Cristóvão, SE, Brazil.
  • de Araújo-Júnior JX; Institute of Chemistry and Biotechnology, Federal University of Alagoas, University City, BR 101, KM 14 Norte, Tabuleiro dos Martins, 57072-970 Maceio, AL, Brazil ; School of Nursing and Pharmacy, Federal University of Alagoas, Av. Lourival de Mello Motta, S/N, Tabuleiro dos Martins, 57072-970 Macei
Biomed Res Int ; 2014: 375423, 2014.
Article en En | MEDLINE | ID: mdl-24995289
ABSTRACT
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Productos Biológicos / Enfermedades Transmisibles / Alcaloides Indólicos / Organismos Acuáticos Límite: Humans Idioma: En Año: 2014 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Productos Biológicos / Enfermedades Transmisibles / Alcaloides Indólicos / Organismos Acuáticos Límite: Humans Idioma: En Año: 2014 Tipo del documento: Article