Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential.
J Colloid Interface Sci
; 431: 194-9, 2014 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-25000181
ABSTRACT
In this study a synthetic approach for the stable, mono-dispersed high yielding bimetallic (Ag-Se) nanoparticles by quercetin and gallic acid is described. The bimetallic nanoparticles were synthesized at room temperature. Different reaction parameters (concentration of quercetin, gallic acid and Ag/Se salt, pH, temperature and reaction time) were optimized to control the properties of nanoparticles. The nanoparticles were characterized by various analytical techniques and their size was determined to be 30-35 nm. Our findings suggest that both the reduction as well as stabilization of nanoparticles were achieved by the flavonoids and phenolics. This study describes the efficacy of quercetin and gallic acid mediated synthesis of bimetallic (Ag-Se) nanoparticles and their in vitro antioxidant, antimicrobial (Gram-positive and Gram-negative bacteria) and antitumor potentials. The synthesized Ag-Se nanoparticles were used as anticancer agents for Dalton lymphoma (DL) cells and in in vitro 80% of its viability was reduced at 50 µg/mL.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Quercetina
/
Selenio
/
Plata
/
Bacterias
/
Nanopartículas del Metal
/
Ácido Gálico
/
Linfoma
/
Antiinfecciosos
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2014
Tipo del documento:
Article