Serum levels of tenascin-C variants in congestive heart failure patients: comparative analysis of ischemic, dilated, and hypertensive cardiomyopathy.
Clin Lab
; 60(6): 1007-13, 2014.
Article
en En
| MEDLINE
| ID: mdl-25016707
ABSTRACT
BACKGROUND:
Tissue remodelling in ischemic cardiomyopathy (ICM), dilated cardiomyopathy (DCM), and hypertensive heart disease (HHD) is accompanied by the re-occurrence of fetal tenascin-C (Tn-C) variants. The study was aimed to comparatively analyze the serum levels of Tn-C containing the FNIIIB (B+ Tn-C) or FNIIIC (C+ Tn-C) domain in heart failure patients due to ICM, DCM, and HHD.METHODS:
119 male patients with congestive heart failure (45 with ICM, 43 with DCM, 31 with HHD) were included. Measurement of serum levels of B+ and C+ Tn-C was performed using Enzyme Linked Immunosorbent Assay (ELISA). Results were correlated to clinical, laboratory, echocardiographic, and spiroergometric parameters.RESULTS:
Analysis of Tn-C concentrations according to heart failure etiology revealed no significant differences. There was an association of C+ Tn-C serum levels to enlargement of the left atrium in DCM (p < 0.01) and the left ventricle in HHD (p < 0.05). In patients with ICM, C+ Tn-C showed a strong negative correlation to the stress test performance (p = 0.002, R2 -0.691). Most strikingly, there was a strong correlation between BNP and B+ Tn-C (p = 0.038, R2 0.466) as well as C+ Tn-C (p = 0.001, R2 0.814) in DCM patients.CONCLUSIONS:
The present study highlights the impact of Tn-C variants as biomarkers reflecting the extent of cardiac remodeling in heart failure patients. Furthermore, B+ Tn-C can be suggested as an additional tool to estimate ICM performance in patients. Especially in combination with BNP, analysis of Tn-C might pave the way for a more precise evaluation of heart failure patients.
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Banco de datos:
MEDLINE
Asunto principal:
Tenascina
/
Insuficiencia Cardíaca
/
Cardiomiopatías
Límite:
Adult
/
Aged
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2014
Tipo del documento:
Article