Evaluation of the maternal-fetal transfer of granisetron in an ex vivo placenta perfusion model.
Reprod Toxicol
; 49: 43-7, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-25019977
ABSTRACT
The objective of this study was to estimate maternal-fetal transplacental passage of granisetron in an ex vivo placental perfusion model. Term human placentas (N=8) were collected immediately after delivery. A single cotyledon from each placenta was perfused granisetron concentration to mimic systemic maternal peak plasma concentrations following either IV (50ng/mL) or transdermal administration (5ng/mL). To assess drug transfer and accumulation, samples were collected from maternal and fetal compartments. In the 50ng/mL open model, the mean transport fraction was 0.21±0.08 with clearance index of 0.53±0.66. Fetal peak concentrations achieved was 5.6±6.6ng/mL with mean accumulation of 5.35±6.4ng/mL. No drug was detected in the fetal compartment with the 5ng/mL models. Transplacental passage of granisetron was inconsistent at the 50ng/mL concentration that achieved with IV dosing. However, there consistently was no detectable passage in all the placentas evaluated of the granisetron at 5ng/mL concentration that would be achieved after transdermal patch administration.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Granisetrón
/
Intercambio Materno-Fetal
/
Antieméticos
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Año:
2014
Tipo del documento:
Article