Increased corneal epithelial permeability after overnight sleep.
Invest Ophthalmol Vis Sci
; 55(9): 5718-22, 2014 Aug 12.
Article
en En
| MEDLINE
| ID: mdl-25118261
ABSTRACT
PURPOSE:
To investigate factors of ethnicity, sex, age, and diurnal variation on human corneal epithelial permeability.METHODS:
Data of corneal epithelial permeability to sodium fluorescein (Pdc) were collected from 374 noncontact lens wearers at various times after awakening throughout the day. Mixed-effect models were developed to investigate the association between Pdc and factors of interest, including time awake (TA), age, sex, ethnicity, and interactions of these factors.RESULTS:
Two models evaluated the "Pdc recovery period" from awakening to 2 hours (Model 1) and the "Pdc plateau" period after TA of 2 hours (Model 2). In Model 1, Pdc declined significantly with length of awake time (P = 0.000), and showed higher Pdc with males (P = 0.098), although this sex difference was not observed after 2 hours (Model 2). Both models showed significantly higher Pdc in Asians than in non-Asians (P = 0.000) and increased Pdc with age (P = 0.048, P = 0.001).CONCLUSIONS:
Baseline corneal epithelial barrier function increases after overnight sleep and varies significantly by ethnicity and age.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sueño
/
Epitelio Corneal
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2014
Tipo del documento:
Article