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Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Wang, Lan; Stanley, Mark; Boggs, Jason W; Crawford, Terry D; Bravo, Brandon J; Giannetti, Anthony M; Harris, Seth F; Magnuson, Steven R; Nonomiya, Jim; Schmidt, Stephen; Wu, Ping; Ye, Weilan; Gould, Stephen E; Murray, Lesley J; Ndubaku, Chudi O; Chen, Huifen.
  • Wang L; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Stanley M; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Boggs JW; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Crawford TD; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Bravo BJ; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Giannetti AM; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Harris SF; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Magnuson SR; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Nonomiya J; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Schmidt S; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Wu P; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Ye W; Department of Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Gould SE; Department of Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Murray LJ; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
  • Ndubaku CO; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: ndubaku.chudi@gene.com.
  • Chen H; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: chen.huifen@gene.com.
Bioorg Med Chem Lett ; 24(18): 4546-4552, 2014 Sep 15.
Article en En | MEDLINE | ID: mdl-25139565
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triazinas / Proteínas Serina-Treonina Quinasas / Péptidos y Proteínas de Señalización Intracelular / Inhibidores de Proteínas Quinasas Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triazinas / Proteínas Serina-Treonina Quinasas / Péptidos y Proteínas de Señalización Intracelular / Inhibidores de Proteínas Quinasas Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Año: 2014 Tipo del documento: Article