Adult sinonasal soft tissue sarcoma: analysis of 48 cases from the French Sarcoma Group database.
Laryngoscope
; 125(3): 615-23, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25186315
ABSTRACT
OBJECTIVE:
The aim of this study was to determine the frequency of primary sinonasal adult sarcoma, identify histological subtypes, and analyze prognostic factors. STUDYDESIGN:
Retrospective review.METHOD:
Forty-eight adult sinonasal sarcomas included in the French Sarcoma Group database (Conticabase) were reviewed.RESULTS:
The most frequent tumor types were alveolar rhabdomyosarcoma (33.3%), embryonal rhabdomyosarcoma (14,6%), unclassified sarcoma (14.6%), and leiomyosarcoma (12.5%). All round cell tumors were rhabdomyosarcomas. The 5-year overall survival (OS), metastasis-free survival (MFS), and local recurrence-free survival (LRFS) rates were 62.3%, 73%, and 88.8%, respectively. Histotype was a prognostic factor for OS, MFS, and LRFS, with the worst prognosis associated with rhabdomyosarcomas, regardless of the subtype. The tumor grade influenced the OS and MFS. Surgery was a predictive factor for a complete response.CONCLUSIONS:
These results suggest that sinonasal tract should be considered as an unfavorable site for rhabdomyosarcoma. Moreover, surgery should always be considered in treatment.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Neoplasias de los Senos Paranasales
/
Neoplasias Nasales
Tipo de estudio:
Diagnostic_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País como asunto:
Europa
Idioma:
En
Año:
2015
Tipo del documento:
Article